When printing digitally in full colour, you have the greatest amount of freedom as our printing systems can accept almost anything. Many times when we have clients give us Word or Publisher files (or PDF files created out of those native applications), they are designed in RGB - and our systems simply translate it to CMYK as we print digital full colour.
If your job is produced through the offset-printing process, the file should be created in CMYK for full colour printing and in PMS colours for spot colour printing.
If you are not sure which colour space to use for your next project, our office is only a phone call away - it’s a good idea to call us before you start your design process if you have questions to avoid having to spend additional time later to fix mistakes.